Satoshi Yoshiji, MD, PhD

Satoshi Yoshiji, MD, PhD

Principal investigator. Assistant Professor in the Department of Human Genetics at McGill University. Board-certified endocrinologist.

Using human genetics and multi-omics to identify drug targets and improve clinical care

What we do: Our lab uses human genetics and multi-omics to understand the biology of diabetes, obesity, and cardiovascular diseases and to identify potential drug targets for them, aiming to improve patient care.

Our research focus: Our lab focuses on three main pillars:

  1. Large-scale human genetics and multi-omics analysis for drug target discovery: We use genomics, proteomics, and other omics in combination with genetic epidemiology methods to understand the underlying mechanisms of diabetes, obesity, and cardiovascular diseases, and to identify potential drug targets. omics
  2. Building and analyzing BioPortal: We are creating and analyzing a new multi-ancestry, multi-omics biobank of 12,500 individuals in Montreal to accelerate drug development and advance precision medicine. bioportal
  3. Disentangling the heterogeneity of diabetes and complex diseases: We dissect the genetic heterogeneity of diabetes and complex traits to understand their distinctive biology, identify drug targets, and ultimately promote precision medicine.
    diversity

Who we are: We are a group of ambitious and forward-looking researchers who enjoy science. We are members of McGill University Department of Human Genetics, McGill Genomic Medicine CERC Program, and McGill Genome Centre.
The PI is also affiliated with McGill’s Quantitative Life Sciences Program. He holds a visiting scholar position at the Broad Institute of MIT and Harvard, and the Mass General Brigham Research Institute.

News:
Nov, 2024.
• Our multi-ancestry proteome-phenome-wide MR atlas work is out!
Multi-ancestry proteome-phenome-wide Mendelian randomization offers a comprehensive protein-disease atlas and potential therapeutic targets
Chen-Yang Su, Adriaan van der Graaf, Wenmin Zhang, Dong-Keun Jang, Susannah Selber-Hnatiw, Ta-Yu Yang, Guillaume Butler-Laporte, Kevin Y. H. Liang, Yiheng Chen, Fumihiko Matsuda, Maria C. Costanzo, J. Brent Richards, Noel P. Burtt, Jason Flannick, Sirui Zhou, Vincent Mooser, Tianyuan Lu, Satoshi Yoshiji
medRxiv 2024.10.17.24315553; doi: https://doi.org/10.1101/2024.10.17.24315553.
Interactive browser: https://broad.io/protein_mr_atlas
This was made possible through the collaboration with the Knolwedge Protal Team at the Broad Institute

• Chen-Yang Su, a PhD student at the lab, gave oral presentations at ASHG 2024 and IGES 2024 on our multi-ancestry proteome-phenome-wide MR atlas work.

• Éloi Gagnon has joined our lab. Welcome Éloi!